The 2022 West Nile Virus Season in Greece; A Quite Intense Season

Since 2010, the West Nile virus (WNV) has been established in Greece. We describe epidemiology of diagnosed human WNV infections Greece with a focus on 2022 season. During transmission period, clinicians were sending samples from suspected cases for testing. Active laboratory-based surveillance was performed immediate notification cases. collected clinical information and interviewed patients timely basis to identify their place exposure. Besides serological molecular diagnostic methods, next-generation sequencing also performed. In 2022, 286 infection diagnosed, including 278 symptomatic 184 (64%) neuroinvasive disease (WNND); 33 died. This third most intense season concerning number WNND cases, following 2018 2010. Most (96%) recorded two regions, northern central The strain variant previous years, clustering into Central European subclade lineage 2. quite prompt diagnosis investigation are considered pivotal response, while availability whole genome sequences enables studies disease.